The MakerSpace has multiple options for CNC /routing/milling tasks. The first level is the use of the "Carvey" CNC router, which is very easy to use and can work with both wood and plastic materials. On the second level is the Tormach PCNC 770 which is capable of extremely high-precision and working with more difficult materials such as aluminum and steel.
Because of the training requirements for the Tormach PCNC 770 mill, it is generally not considered a "Rapid Prototyping Tool". For more information on training, please see the "CNC Tools" section under Safety and Manuals.
Carvey CNC Router/Mill
The Carvey is a very fun and simple machine to use. The interface and layout system is incredibly easy and there is no referencing of the material necessary. If you simply add your material to the system and use the "Smart Clamp", most other settings will be handled without questions. A tutorial on using the Carvey can be found here.
You must use the "Easel" system to load the g-code into the Carvey. Easel will create its own g-code based on your drawing, or you can import your own g-code from another CAM software system (such as Autodesk Fusion 360